names: L-PAM, L-Sarcolysin,
form: Alkeran can be taken by intravenous
injection (IV) and/or as tablets by mouth, on an empty stomach.
type: Alkeran is
classified as a nitrogen mustard alkylating agent
available by prescription only
Alkeran is used in the
Breast cancer - in advanced stages or in addition to surgical treatment.
Occasionally, Alkeran is used to treat the following cancers:
- chronic myelogenous leukemia, one
of four main types of leukemia
- Osteogenic sarcoma, one of the
most common forms of bone cancer in children.
Note: your doctor can use the drug to
treat other medical conditions non-mentioned in this article if he believes it can be helpful.
ALKERAN is contraindicated
in the following conditions:
allergy to Alkeran or one of
breastfeeding is not
recommended while taking Alkeran
- using Alkeran is not
recommended during pregnancy, especially during the first quarter; the drug may cause problems which can be
harmful to the fetus
Elderly, infants and children
are treated with Alkeran under strict medical supervision.
If you have one of the following
medical conditions, let it be known to your doctor before beginning an Alkeran treatment:
- glucose-galactose malabsorption
- You have
been treated with radiotherapy or antineoplastic agents during the previous 3
Mechanism of Action
Alkeran destroys cancer cells by forming cross-linkages between DNA strands (deoxyribonucleic acid), which
thereby inhibiting the replication of tumor cells.
: Alkeran may be toxic or cause serious infections when it is associated with nalidixic
, cyclosporine or other immunosuppressants. In addition, the association of high-dose Alkeran and cyclosporine is
toxic to the kidney.
: Alkeran attack not only cancer cells but healthy cells that multiply quickly, which often leads to adverse
effects. The most common Alkeran side effects include:
- loss of
- loss of
- rash and itching
- increased risk of bleeding
- Pulmonary fibrosis (rare)
- Mouth blistering, sometimes inflammation of the
doctor immediately if you experience any of the following symptoms:
black, tarry stools
urine or blood in
of the skin or eyes
risk of infection
breathing or shortness of breath.
For additional information about prostate cancer please