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Alfuzosin (Uroxatral)  


Alfuzosin is a viable anti-cancer drug that is used to treat pain and symptoms associated with Benign Prostatic Hypertrophy (BPH): difficulty urinating (hesitation, dribbling, weak stream, and incomplete bladder emptying), painful urination, and urinary frequency and urgency. This drug works by relaxing the muscles in the prostatic gland and bladder neck, which in return allows the patient to urinate easier.  The medication can be taken orally, as prescribed by the medical practitioner.  


Indications: Alfuzosin is mainly indicated to treat BPH (Benign Prostatic Hyperplasia) patients. It is also used as an adjunctive drug for patients suffering from high blood pressure. 


Patients having BPH, having enlargement of their prostate gland, usually experience consequently feel pressure on tissues surrounding their prostate. The inflation of the prostate gland reduces flow of urine and also leads to other associated urinary problems. Since BPH is a non-cancerous swelling of prostate, it can be easily treated with Alfuzosin with no surgical intervention.  


This drug is indicated for following purposes:   

  • For relaxing muscles that surround prostate and bladder in order to facilitate easy flow of urine 
  • For relieving various indications of onset of BPH like painful urination followed by inflammatory sensation; feeling of incomplete evacuation; irritation and pain in bladder, etc. 
  • For acting positively on the prostate tissues to relax and relieve them of pain and stiffness 

Dosage: The adult dosage of Alfuzosin has to be 2.500 to 10.000 mg after every 8 hours for number of days prescribed by the health care professional. 


Contraindications: Alfuzosin is contraindicated in these conditions:  


  • If patient feels dizzy or giddy while sitting, standing or even while lying in rest position 
  • If patient has fainted after urinating 
  • If patient has ever experienced any allergic effect to Alfuzosin or any of its compounds 
  • If patient suffers from angina 
  • If patient suffers from kidney or liver related ailments  
  • If patient is experiencing ‘Intraoperative floppy iris syndrome’ after undergoing cataract removal. 
  • If patient is suffering from mild to moderate liver damage (this medical condition raises the level of alfuzosin in blood) 
  • Persistent low blood pressure 
  • Feeling of dizziness or giddiness after intake of this drug.

Mechanism of Action (MOA): Alfuzosin is a derivative of quinazoline that demonstrates preference of α1-adrenergic receptors in urinary tract (lower). When these adrenoreceptors are blocked, the muscles in the prostate and bladder neck get relaxed. This improves flow of urine and diminishes irksome symptoms of benign prostatic hyperplasia. 


Absorption – Alfuzosin gets readily absorbed after oral intake. Its bio-availability is nearly 64%. 

Distribution – Alfuzosin is 90 percent bound to plasma proteins 

Metabolism – Alfuzosin gets metabolized in liver through cytochrome P450 isoenzyme CYP3A4. 

Excretion – Nearly 11% of Alfuzosin gets excreted through urine. The metabolites of this drug get excreted in faeces through bile. 


Interaction: The medication shows interaction with drugs like Halothane, Atenolol, Moxisylyte. When taken in conjunction with these drugs, Alfuzosin might lead to the development of few complications. 


Side Effects: Following are some of the side effects of Alfuzosin that must be reported to doctor:

  • Fainting 
  • persistent low blood pressure 
  • chest pain 
  • unexplained rashes & itching 
  • hives, 
  • fatigue 
  • headache 
  • abdominal pain 
  • heartburn 


  • indigestion
  • swelling 
  • difficult breathing with wheezing sound 
  • dizziness 
  • infection in upper respiratory tract 
  • constipation 
  • nausea 
  • bronchitis 
  • sore throat and sinus infections