Cephalexin is a
cephalosporin antibiotic. Cephalosporins are 7-aminocephalosporic acid derivatives that are structurally very
closely associated with penicillin. Cephalosporins possess a six tiered sulfur ring bordering a ß lactam ring.
Cephalexin is recommended to patients suffering with irritations in their
prostate gland. It is also used to
treat various bacterial infections including respiratory tract inflammation, urinary tract and skin
infections. Since Cephalexin is an antibiotic drug, it has to be taken consistently after regular intervals for
optimum therapeutic effect. Any discontinuation in taking this drug will not render effective
medicationcomesas a capsule,
tablet, and liquid to take by mouth. Cephalexin capsules and oral
suspensions are used for treating or preventing infections that are suspected to be bacterial in nature. This
drug is indicated for treating the following medical conditions:
- Infections in
respiratory tract caused by S. pyogenes and S. pneumoniae
- Otitis caused by H.
influenzae, S. pneumoniae, staphylococci, M. catarrhalis, streptococci
- Skin infections and
inflammations caused by streptococci, and/or staphylococci
- Bone infections due
to P. mirabilis and/or staphylococci
- Infection in
Genitourinary tract caused by P. mirabilis, E. coli, and K. pneumoniae.
Cephalexin can be administered orally in the following dosages:
Its adult dosage is from 1 to 4 g daily in divisions of 6 hours. Doctors prescribe Cephalexin in dosage of 500 mg
every 12 hours for Streptococcal pharyngitis, uncomplicated
cystitis and Skin structure infections, for patients above 15 years of
The recommended daily dosage of Cephalexin for pediatric patients is 25 to 50 mg, in divisions of 12
In case of severe infections, the dosage of Cephalexin is doubled.
Contraindications: Cephalexin is
contraindicated in following conditions:
- When patient is allergic to the
cephalosporin range of antibiotics
If patient has suffered a renal failure
During lactation process.
Mechanism of Action (MOA):
Cephalexin Cephalexin is acid stable and can be given even without meals. It tends to get quickly absorbed after
oral intake. It gets excreted via urine through tubular secretion and glomerular filtration. Studies have proven
that more than 90% of the unaffected drug gets excreted through urine within 8 hours of intake. According to in-vitro tests, cephalosporins are bactericidal due to their
reservation for cell-wall synthesis. This drug has also proven to be dynamically active against in-vitro as well as
clinical infections. This drug stalls or slows the proliferation of bacterial
cells and prevents the bacteria from forming its cell wall thus disabling it to survive.
shows interaction with following drugs:
omega-3 polyunsaturated fatty acids
occurrence of Cephalexin side effects is a subjective issue. However, one must be aware of probabilities to
avoid further serious medical complications. If following effects are experienced after taking Cephalexin,
immediate medical attention might be necessary:
rashes associated with fever
- itching, hives or
- swelling of