Cisplatin (Platinol, Platinol®-AQ)
Cisplatin (also called Platinol and
Platinol®-AQ) is a drug used to treat many types of cancer including prostate cancer. It belongs to a group
of chemotherapy medicines which are generally known as alkylating agents. It is an anti- cancer or cytotoxic
Indications: Cisplatin is mainly indicated for the treatment of
prostate cancer, lung cancer, breast cancer, head cancer, ovarian cancer, bladder cancer, testicular cancer,
cervical cancer and stomach cancer. It is also indicated for treatment of multiple myeloma, melanoma and
Dosage: Cisplatin is an intravenous drug which is given through
the vein. The drug is generally available in two forms, Injectable solution and powder for injection. The
Injectable solution is of 1mg/ml and the powder is available in 10 mg and 50 mgs. The dosage may differ
depending upon the types of cancers and the severity of the disease. For instance, for metastatic testicular
tumors, usual dosage would be 20 mg/sq.meter/day IV for 5 days/cycle; for advanced bladder cancer, dosage is 50
-70 mg/sq. for 3 to 4 weeks, depending on previous radiation therapy or chemotherapy. In case of metastatic
ovarian carcinoma, 75-100 mg/sq. meter for 4 weeks with cyclophosphamide (600 mg/sq. for 4Weeks) is to be
Dosage for cancer of
cervix, prostate, oesophagus, kidney, osteogenic sarcomas, bone marrow transplants are 75-100 mg/sq.meter IV
q4Weeks when used with cyclophosphamide and100 mg/sq.meter IV q4Weeks as single agent. The dosage and the number
of days may differ as prescribed by the oncologist.
occur in Cisplatin usage under the following circumstances:
If the patient is allergic to any of
the components of Cisplatin.
If the patient is suffering from
nausea and/or constipation
If the patient is suffering from any
kidney ailments or anaemia, the dosage of Cisplatin may cause reversible effects
Any type of vaccinization is not
advisable without the doctor’s approval during the treatment.
Mechanism of Action (MOA): The drug Cisplatin works in reduction of the cancer cells
which grow with the help of testosterones (male hormones) so that the cancer growth gets minimized. This drug is
an alkylating agent that work through three mechanisms:
It gets attached to DNA bases
causing fragmentation of DNA and preventing their consequent synthesis.
It damages DNA by forming
cross-links (inter-atomic DNA bonds) that prevents DNA synthesis
Initiating mispairing of nucleotides
that may lead to their mutations.
Interactions: Cisplatin is an alkylating agent and the usage of this
drug with other alkylating drugs may cause increased risk of side effects. If a combination of medicines is
prescribed by the doctor, the dose and the usage gap of the medicine may differ. Some of the other alkylating
medicines are Aldesleukin, Docetaxel, Tobramycin, phenytoin etc. Along with the Cisplatin, Lomustine, Carmustine
and streptozocin are also used in treatment for brain tumors.
Effects: Intake of Cisplatin may
lead to severe allergic reactions or kidney problems. There may be also problems like loss of hearing (commonly
in children), bleeding, weak immunity, bone marrow suppression, vomiting or nausea.
Over doing of this drug
may cause urinary problems, skin rashes, difficult breathing, and dizziness.