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Doxazosin (Cardura, Cardura XL)  

Doxazosin is a medication commonly used to hypertension (high blood pressure) and benign prostatic hyperplasia (enlarged prostate). This drug can be effective in treating symptoms benign prostatic hyperplasia (BPH) such as difficulty urinating (hesitation, dribbling, weak stream, and incomplete bladder emptying), painful urination, and urinary frequency and urgency. 

 

Indications: Doxazosin is indicated in the treatment of high blood pressure caused by the narrowing of the arteries that consequently block the flow of blood through the blood vessels. This drug works by relaxing the veins and arteries so that the flow of blood becomes smooth and free. Doxazosin is also used in the treatment of Benign Prostatic Hyperplasia, an enlargement of prostate gland in men. The prostate gland in men is enlarged due to many reasons and blocks the flow of urine from the urethera to the bladder. This drug is used to reduce the size of the enlarged prostate, thus reduce or eliminate the symptoms of the disease.  

 

Dosage: Doxazosin may be taken once, orally, with or without food, daily around the same time for best results. Basically, the dosage is given depending up on the medical condition of the patient and his responsiveness to the therapy. The dosage given by the doctor should be followed strictly as this drug causes dizziness or fainting when consumed in excess. In such case the medication may be stopped gradually after the consultation with the doctor.  

 

Contraindications: The drug may face contraindications in the following conditions: 

  • If the patient is sensitive to Doxazosin or any of its components 
  • If the patient is suffering from impaired liver function 
  • If the patient is pregnant or a lactating mother 

Mechanism of Action (MOA):  Doxazosin works on alpha adrenergic group that is beneficial in the treatment of benign prostatic hyperplasia and high blood pressure (hypertension). The medication acts on the prostate gland by decreasing the enlargement. After assimilation of the medication, about 4.8% of the drug’s doses get excreted through feces with slight traces of radioactivity present in the urine. 

 

Interactions: Patients receiving this drug barely experience any interaction. In fact, the medication can be taken along with thiazide diuretics, beta-blocking agents and non-steroidal anti-inflammatory drugs without experiencing any adverse effect. 

 

Doxazosin is 98% protein bound and hence there is no effect on protein binding of drugs such as digoxin, warfarin, phenytoin and indomethacin. However, acetaminophen, aspirin, codeine and codeine combinations, ibuprofen, erythromycin, trimethoprim and sulfamethoxazole, amoxicillin, chlorpheniramine, atenolol, hydrochlorothiazide, propranolol, hypoglycemics and endocrine drugs should be taken with precaution along with Doxazosin.  

 

Side Effects: the following are the possible side effects of Doxazosin:  

  • Allergic indications in the form of rashes, hives and fever 
  • Swollen face, tongue or lips 
  • Difficult breathing and tightness in throat 
  • Rapidly pounding heartbeats 
  • Giddiness, fainting spells and light-headedness 
  • Pain and discomfort at the time of passing urine 
  • Swelling of limbs or localized fluid retention and tissue  
  • Painful erection or ejaculation 
  • Fatigue and weakness