(Eulexin) is an antiandrogen (or androgen antagonist) chemotherapy drug which
works to prevent the actions of male hormones (androgens). This medication is used mainly in the treatment of
prostate cancer. Testosterone is a natural hormone that promotes the growth of prostate cancer cells and their
spread to other parts of the body. Flutamide drug helps in jamming the effects of the testosterone and thereby
restricts the growth of the tumor in the prostate gland.
Indications: Eulexin is
indicated in the treatment of prostate cancer and rarely other malignant tumors. This drug is usually indicated
for use in combination with LHRH agonists (another type of hormone therapy) for the administration of locally
restrained metastatic carcinoma of the prostate. For stage B2 – C Prostatic Carcinoma, the treatment with the
drug and LHRH agonist is to be started 8 weeks before the radiation therapy. For stage D2 – C Metastatic
Carcinoma, benefits can be achieved by continuing treatment with the drug as well as LHRH agonists.
Dosages: Eulexin comes
in capsule form. Each capsule contains 125 mg flutamide and the compound has a molecular weight of 276.2. Two
capsules 3 times a day at an interval of 8 hours sums up to a total dosage of 750mg per day. This may differ as
prescribed by the doctor. Dosage of 1500 mg per day up to 36 weeks renders no serious adverse effects.
Gynecomastism (abnormal development of large mammary glands in males resulting in breast
enlargement) and breast tenderness are some of the adverse
reactions reported when the drug is consumed in excess.
(flutamide) is contraindicated in groups of patients, mainly patients who are allergic or hypersensitive to
flutamide or any of its components. The drug is not recommended in patients who suffer from serious liver
problems or liver failure. Contraindications may occur in patients who are suffering from a lung disease or for
those who have hemoglobin M deficiency.
Mechanism of Action: Eulexin
directly works by preventing the cancer promoting activities of androgens. Control of metastatic prostate cancer
is based on androgen removal. Combination of Eulexin with LHRH intends to achieve maximum androgen blockade.
Rarely, the uses of Eulexin medicines cause severe liver problems. The dosage should not be stopped without the
permission of the doctor.
Interactions: Risk of side
effects may increase if this drug is used in combination with any other drug. Testosterone (gel or injection),
anabolic steroids, warfarin are some of the drugs which interact with Eulexin.
Side Effects: there are possible side effects of Eulexin in all patients taking the medication. Recurrent
allergic reactions in the form of forced breathing, tightness in throat, swelling of tongue, lips, face; or
development of hives. Patients may experience hot flashes, rashes on skin, skin sensitivity towards sunlight,
decrease in sex drive, low sperm count, impotence, blood traces in urine, and discoloured urine. Bleeding in
rectum with can be accompanied with severe inflammation. In odd cases, Eulexin may also cause serious liver
damage. Its symptomatic warnings can be nausea, abdominal pain, vomiting, unusual fatigue, yellow eyes or skin,
and dark stools or urine.
Severe and worrisome side
effects must be reported to doctor at earliest to avoid further medical complications.