Lupron (Lupron Depot)
Prostate cancer is the most common
type of cancer that affects men. Malignant cells are formed in the prostate gland and cause its enlargement.
Though the symptoms of prostate cancer are many, most common includes pain in the pelvic area, frequent
urination, pain during urination and even back pain. There are many treatments available for prostate cancer
like surgery, radiation therapy, chemotherapy and so on. Along with such treatments the doctors also prescribe
drugs to prevent the growth of the cancer cells and also control the tumor from spreading to other parts. One
such drug that is commonly used for prostate cancer treatment if Lupron (Lupron Depot).
Indications: Prostate cancer creates lot of uneasiness in the life of
the patient which makes surgery and/or other treatment options become a must. The cancer cells in the prostate
gland stimulate the male hormone testosterone and that multiplies at an uncontrollably rate. Lupron plays a
major role in reducing the spread of the cancer cells and also control the growth of the testosterone. Beside in
the treatment of prostate cancer, Lupron injection is also used for reducing the early puberty problems in
children. It reduces the sex hormones in children to control their puberty and the height
Dosage: The Lupron injection is prescribed for one dose every
day. The frequency of the dosage depends upon how the patient would react to the drug. While prescribing to
children, the dosage mainly depends on the height and weight of the child. Usually it’s advisable to stop the
intake of Lupron much before the age of 11 years for girls and before 12 years in boys.
Contraindication: The Lupron also contains Benzyl alcohol which could
create some allergic reaction in some patients. Also, there have been indications where many patients, suffering
from osteoporosis, experienced an increase in the bone loss. The doctor must be informed in advance if the
patient is already undergoing treatment for any other diseases. In case the patient is diabetic or suffering
from any heart disorders, doctor must be consulted before taking this drug.
Mechanism of Action
(MOA): Lupron acts like a
restrainer of gonadotropin secretion and is successful in suppressing testicular and ovarian steroidogenesis
(production of steroids). However, this effect reoccurs on discontinuation of
this drug. This drug is really beneficial in curtailing the growth of those tumors that rely on hormones.
Interaction: Lupron, although does not have any notable interaction
with other drugs, can interact with certain medications. It’s recommended to inform doctor of all the drugs and
medications that you are already taking. Certain medicines like Phenytoin, Prednisone and corticosteroids, and
few anti-seizure drugs may interact with Lupron.
If a patient experiences any of the following
side effects, doctor should be consulted at earliest:
- Hot flashes, pain in
joints and back, pain in the injection and fatigue
- Erectile Dysfunction
- Pain at the time of
urinating, nocturia or other urinary symptoms
- Rashes, hives or any
other visible skin reaction
- Itching or irritation
in genital area especial in penile area.