Brand name: Megace, Megace
Other names: Megestrol Acetate
Manufacturer / Distributor:
Megace is available by prescription only
Indications: Megace is
used to treat the following cancers:
advanced breast cancer
Advanced endometrial cancer (also called
Megace is also used to treat
malnutrition, loss of appetite and weight loss in patients with AIDS. That is, by using Megace, you can have
your appetite and weight increased.
Megace comes as a
tablet, a suspension (liquid) and a concentrated suspension (called Megace ES) to take by
Dosage: to prescribe a dose of Megace which is
able to fight your disease, your doctor will consider the type of medical condition you have, your health status
(presence of other diseases or not), and your body surface area (BSA). If you are taking other medication (s),
you can be prescribed a lower dosage of Megace.
In the case of breast cancer, your
oncologist may recommend you to take three or four doses of 40 mg of Megace daily with or without food; usually
the maximum dose is 160 mg per day. For cancer of the endometrium, the usual dose is 80 to 320 mg per day, which
can be divided into doses of 40 to 80 mg administered 1-4 times per day; or one or two 160 mg tablet per day
with or without food. Usually, the recommended dose in the treatment of prostate cancer is a single dose of 120
mg daily, combined with diethylstilbestrol. It is important that you take the medication around the same time
In some cases, your doctor can
indicate different doses. It is necessary that you follow the indications exactly throughout the treatment. If
you experience serious side effects or complications, contact your doctor immediately. Do not change or stop taking the medication without first consulting your
Always shake the liquid well before
Talk to your doctor or pharmacist for
information on the use of Megace in the treatment of acquired immunodeficiency syndrome (AIDS).
Storage: store Megace at room temperature, away
from direct sunlight, moisture and heat above 40 ° C. Keep Megace out of the reach of children. Do not store Megace and all medications in the bathroom. Megace and all other medications
should not be used beyond the expiration date printed on the container.
Overdose: Do not take Megace more often than
prescribed by your doctor. As with any drug, persistent overdose can be dangerous. If you think you
have taken an overdose of Megace, contact your doctor or a poison control center near you as soon as possible.
do your best to take
Megace as indicated by your doctor or pharmacist.
In case you forget to
take a dose, take the missed one as soon as you remember it. However, if it is almost time for your next
do not double the next dose to recover the missed one; it can be dangerous. Contact your doctor or wait to go back
to your regular schedule.
contraindicated or should be used with precautions in case of the following conditions:
allergy to Megace or
one of its ingredients
doctor is you have a history of stroke, diabetes, kidney or liver disease, and blood clot.
Mechanism of action (MOA): Megace is a progesterone; it slows or
stops the multiplication of cancer cells in the prostate by inhibiting the production of testosterone in the
body. In the treatment of breast or endometrial cancer, Megace interfering with other hormones and proteins
necessary for the division of the cancer cells.
Interactions: talk you to your doctor before taking
vitamins, nutritional supplements or St. John wort.
Some medications can interact with Megace
. Tell your doctor and pharmacist if you are taking any medication.
effects: in certain
patients, Megace can lead to
increased blood pressure
rapid or unusual weight gain
gas or bloating
decreased sexual desire
unexpected vaginal bleeding
lack of energy
breast tenderness or pain
Appearance of brown spots on exposed skin.
If the side
effects above persist for weeks, contact your oncologist. In addition, contact your doctor if you experience any
of these symptoms:
fast or irregular heartbeat
excessive sweating, mainly at
purple, blue, or black discoloration of the
chest pain or heaviness in
weakness or numbness of an arm or
pain or swelling in the
Swelling of face, ankles or feet.
For additional information about prostate cancer please