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Taxotere (Docetaxel)  

Taxotere (Docetaxel) is an antineoplastic which belongs to the taxoid family, a class of chemotherapy drugs derived from yew tree products. The medication comes in a white powder form with a molecular weight of 861.9 and also insoluble in water. This drug is used in the treatment of many cancers including prostate cancer.  

 

Indications: Taxotere (Docetaxel) is indicated for treatments of cancers such as breast cancers, advanced stomach cancers, cell lung cancer, head and neck cancer and metastatic prostate cancer.  Apart from these, small-cell lung cancers, ovarian cancer, pancreatic cancer, melanoma and soft tissue sarcoma are the few diseases for which the medication is recommended.  

 

Dosage: Taxotere (Docetaxel) is a sterile injection concentrate which is pale yellow to brownish yellow solution. It is available in vials containing 20 mg or 80 mg for single use.

 

The dosage of Taxotere is given intravenously and it has no tablet form. Medication of corticosteroid pill is normally infused prior to the treatment of Docetaxel in order to lessen the severity of fluid retention and allergic reactions. The amount of dosage may differ depending on the factors including, height and weight of the patient, type and severity of the disease, and the general health of the patient. 

 

Contraindications: Taxotere (Docetaxel) may be contraindicated in following cases: 

  • If the patient has received any kind of immunization or vaccination before the treatment,  
  • If the patient is pregnant (the drug may be hazardous to the foetus), 
  • If the patient is allergic to any of the components of the drug or to other penicillins, 
  • If the patient is suffering from a kidney disease 
  • Risk of infections is high when this drug is used.

Mechanism of Action (MOA): Taxotere stalls the growth of cancerous depending upon the formation of microtubules, an internal cellular skeleton. At the time of cell development process, microtubules tend to first come together and then disassemble. This permits cancerous cells to split and let tumor grow further. This drug freezes the internal skeleton of cancerous cells by jamming the microtubules. This action causes death of malignant cells and prohibits division of cancerous cells.  

 

Interactions: Some of the medicines that may interact with this drug include:  

  • Azole antifungals (like itraconazole) 
  • Macrolide antibiotics (like erythromycin) 
  • Rifamycins (like rifabutin) 
  • HIV drugs (like ritonavir) 

Side Effects: Some of the side effects felt immediately after receiving an injection of this drug are dizziness, light-headedness, itching in the injected site, heavy breathing, and tightness in chest. Administration of this drug can also result in some allergic reactions like rashes, hives, swelling of lips, face, throat or throat, and skin eruptions. 

 

On experiencing any of the following serious side effects, get medical attention as soon as possible:  

  • Easy bleeding or bruising 
  • Unusual fatigue or weakness 
  • Giddiness and fainting spells 
  • Chills, fever, symptoms of flu or body aches 
  • Severe diarrhea 
  • Discoloration of skin 
  • Feeling of nausea, fever, and weak appetite 
  • Shortness of breath even after mild exertion 
  • Swelling of joints 
  • Development of sores or white patches inside mouth or on lips 
  • Changes in menstruation cycle